[Reaction of the body to the effect of barbiturates and the activity of monoaminergic processes in the brain].

The adaptive reaction to barbiturates was studied in the presence of a seasonally varying monoamine content and metabolism in the brain. The effectiveness of amobarbital and monoamine content in mouse brain were determined monthly during 5 years. It has been demonstrated that both adaptive reactivity of mice and monoamine content in the brain show a similar seasonal periodicity. The conclusion is made that adaptive reactivity determining the depth and duration of amobarbital anesthesia correlates mainly with the activity of serotoninergic processes. Activation of adaptive reactions caused by repeated administration of the barbiturate correlates with the activity of dopaminergic processes.