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[派丽多对大鼠小肠功能和形态学特征的影响]

[Effect of peritol on the functional and morphological characteristics of the small intestine in rats].

作者信息

Brodskiĭ R A, Dedenkov A N, Iavor T, Khachirov D G, Bandurko L N

出版信息

Farmakol Toksikol. 1983 May-Jun;46(3):67-71.

PMID:6861992
Abstract

Experiments were made on 140 male Wistar rats with the use of morphological, biochemical and radiometric research methods. It was established that as soon as the treatment with the anabolic drug peritol was completed, there appeared the morphological signs attesting to an increase in functional activity of vasculostromal elements of the small intestine, and the absorption rate of vitamin B12 got intensified. Activity of enzymes responsible for parietal digestion (alkaline phosphatase, invertase), absorption of 59Fe-citrate and 131I-albumin were unchanged. No substantial changes were revealed on the part of the morphology and function of the small intestine in the long-term period after peritol administration.

摘要

使用形态学、生物化学和放射测量研究方法对140只雄性Wistar大鼠进行了实验。结果表明,一旦完成同化激素药物培多普利的治疗,就出现了形态学迹象,证明小肠血管基质成分的功能活性增加,维生素B12的吸收率增强。负责壁内消化的酶(碱性磷酸酶、转化酶)、柠檬酸铁59和碘131白蛋白的吸收活性没有变化。在给予培多普利后的长期内,小肠的形态和功能没有发现实质性变化。

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