Katz L D, Glickman M G, Rapoport S, Ferrannini E, DeFronzo R A
Diabetes. 1983 Jul;32(7):675-9. doi: 10.2337/diab.32.7.675.
Oral glucose (92 g) was administered to 22 healthy, young volunteers undergoing hepatic vein catheterization, and net splanchnic glucose output (SGO) was measured during the basal period and for 4 h after glucose ingestion. In the basal state, SGO averaged 1.90 +/- 0.11 mg/min X kg. After glucose, SGO rose to a peak value of 6.65 +/- 0.83 mg/min X kg at 30 min and returned to baseline by 3 h. Total SGO over 4 h was 69 +/- 4 g; assuming complete absorption of the load, this amount represented 75% of the oral glucose. In a subgroup of six subjects, leg glucose uptake was simultaneously quantitated by femoral vein catheterization and leg blood flow measurement. In the postabsorptive state, glucose uptake by one leg was 24 +/- 8 mg/min and increased to a mean value of 76 +/- 7 mg/min during the 4 h after glucose ingestion. Overall, 18 +/- 2 g/4 h of glucose were taken up by one leg, which extrapolates to a total body muscle uptake of 65 +/- 4 g over 4 h. We conclude that in normal man, well over 2/3 of an oral glucose load escapes splanchnic removal, and that the peripheral tissues quantitatively play the dominant role in glucose disposal.
给22名接受肝静脉插管的健康年轻志愿者口服葡萄糖（92克），并在基础期及摄入葡萄糖后4小时测量内脏葡萄糖净输出量（SGO）。在基础状态下，SGO平均为1.90±0.11毫克/分钟×千克。摄入葡萄糖后，SGO在30分钟时升至峰值6.65±0.83毫克/分钟×千克，并在3小时时恢复至基线水平。4小时内的总SGO为69±4克；假设负荷完全吸收，该量占口服葡萄糖的75%。在6名受试者的亚组中，通过股静脉插管和测量腿部血流同时定量腿部葡萄糖摄取。在吸收后状态下，一条腿的葡萄糖摄取量为24±8毫克/分钟，在摄入葡萄糖后的4小时内增加至平均值76±7毫克/分钟。总体而言，一条腿在4小时内摄取18±2克/4小时的葡萄糖，据此推算全身肌肉在4小时内摄取65±4克葡萄糖。我们得出结论，在正常男性中，超过三分之二的口服葡萄糖负荷未被内脏清除，并且外周组织在葡萄糖处置中在数量上起主导作用。
