de Wolff F A, Edelbroek P M, de Haas E J, Vermeij P
Hum Toxicol. 1983 Apr;2(2):385-9. doi: 10.1177/096032718300200235.
1 Abuse of laxatives may lead to a variety of serious disorders which are usually difficult to recognize because of the heterogenicity of the toxic effects. 2 In order to facilitate the diagnosis of chronic laxative poisoning, a laboratory screening method for the detection of colonic stimulants in urine has been designed and has been applied in practice over a three-year-period. 3 During this period, 157 samples from 81 patients were sent to the laboratory. Fifteen patients (18.5%) were definitely shown to use self-prescribed laxatives. 4 Next to the diphenolic compounds: bisacodyl, phenolphthalein and bisoxatin, the anthraquinone derivative rhein, a metabolite of vegetable laxatives, was found in several cases. In the urine of three patients a substance resembling rhein was found, which was shown to be aloe-emodin. 5 It is concluded that chronic self-poisoning with laxatives is a fairly common disorder than can easily be overlooked. Laboratory screening of the urine of suspected patients is an economic and reliable method for its diagnosis.
滥用泻药可能导致多种严重疾病，由于毒性作用的异质性，这些疾病通常难以识别。
为了便于慢性泻药中毒的诊断，设计了一种检测尿液中结肠刺激剂的实验室筛查方法，并在三年时间里应用于实际。
在此期间，来自81名患者的157份样本被送往实验室。15名患者（18.5%）被明确证明自行服用泻药。
除了双酚类化合物：比沙可啶、酚酞和双醋苯啶外，在几例病例中还发现了植物性泻药的代谢产物蒽醌衍生物大黄酸。在三名患者的尿液中发现了一种类似大黄酸的物质，经证实为芦荟大黄素。
得出的结论是，慢性泻药自我中毒是一种相当常见但容易被忽视的疾病。对疑似患者的尿液进行实验室筛查是一种经济且可靠的诊断方法。
