McLaughlin C W, Coe J D, Adwers J R
Am J Surg. 1978 Aug;136(2):250-3. doi: 10.1016/0002-9610(78)90239-8.
A consecutive series of 435 patients with breast cancer followed from six to thirty years is presented. Radical mastectomy was the surgical procedure of choice and our experience indicated that the degree of axillary nodal involvement is a most important guide in establishing prognosis in this disease. The majority of recurrences became evident within the first five postoperative years, the next most hazardous period for the patient being the half decade between the fifth and tenth years after initial therapy. A second independent malignancy developed in 37 of the 275 pateints who died, and it was the cause of death in 7.6 per cent of this group. Among the 160 patients still living to date a second independent malignancy has already developed in 10. Bilateral breast cancer was observed thirty-eight times in this entire series of 435 patients, an incidence of 8.7 per cent.
本文呈现了一组连续的435例乳腺癌患者，随访时间为6至30年。根治性乳房切除术是首选的手术方式，我们的经验表明腋窝淋巴结受累程度是确定该疾病预后的最重要指标。大多数复发在术后头5年内显现出来，对患者来说下一个最危险的时期是初始治疗后第5年至第10年这5年期间。在275例死亡患者中，有37例发生了第二种独立的恶性肿瘤，且在该组患者中有7.6%的患者死于第二种独立的恶性肿瘤。在至今仍存活的160例患者中，已有10例发生了第二种独立的恶性肿瘤。在这435例患者的整个系列中，观察到双侧乳腺癌38例，发病率为8.7%。
