Max J P, Bach A, Pallier E, Schirardin H, Debry G
Int J Obes. 1983;7(2):161-5.
The influence of a diet including 18 per cent by weight of long-chain (LCT) or medium-chain (MCT) triacylglycerols on adipose tissue development, and on in-vitro adipose tissue triacylglycerol (TG) synthesis from glucose and palmitic acid, was studied using genetically obese, fa/fa, and control, Fa/-, Zucker rats. The adipose tissue mass was greater with the LCT diet than with either the MCT or control diets, but there was no significant difference between the MCT and control diets. TG synthesis from labelled substrates was not modified by the MCT diet when compared with the control, but was decreased by the LCT diet. The results suggested that the use of MCT in treating human obesity would necessitate levels too high to be therapeutically practical.
使用遗传性肥胖的fa/fa Zucker大鼠和对照Fa/- Zucker大鼠，研究了含有18%（重量）长链（LCT）或中链（MCT）三酰甘油的饮食对脂肪组织发育以及体外脂肪组织从葡萄糖和棕榈酸合成三酰甘油（TG）的影响。与MCT饮食或对照饮食相比，LCT饮食的脂肪组织质量更大，但MCT饮食和对照饮食之间没有显著差异。与对照相比，MCT饮食对标记底物的TG合成没有影响，但LCT饮食使其降低。结果表明，在治疗人类肥胖中使用MCT所需的剂量过高，在治疗上不具实用性。
