Bonora G M, Moretto V, Toniolo C, Anzinger H, Mutter M
Int J Pept Protein Res. 1983 Apr;21(4):336-43. doi: 10.1111/j.1399-3011.1983.tb03113.x.
Conformational studies of X[-L-Tyr(Bzl)-]n-series bound to polyethyleneglycol (X = H2, Nps; n = 3-8) in the solid state and in solvents of different polarities and capabilities of forming hydrogen bonds are reported. By using i.r. absorption, the occurrence of the beta-structure in the higher oligomers in the solid state was established. By means of i.r. absorption and CD the onset of that ordered conformation in solution was assessed as a function of chain length. The effects induced by the presence of the N-protecting group and added base, and by changing the nature of solvent on the conformational preferences of the [-L-Tyr(Bzl)-]n homo-peptides were also examined. The 2-nitrophenylsulphenyl chromophoric derivative of the alpha-amino group is proposed as a circular dichroism sensor for beta-structure in peptides.
报道了与聚乙二醇结合的X[-L-酪氨酸（苄酯）-]n系列（X = H2、Nps；n = 3 - 8）在固态以及在不同极性和形成氢键能力的溶剂中的构象研究。通过红外吸收，确定了固态中较高寡聚物中β-结构的存在。借助红外吸收和圆二色性，评估了溶液中该有序构象的起始情况与链长的关系。还研究了N-保护基团和添加碱的存在以及改变溶剂性质对[-L-酪氨酸（苄酯）-]n同型肽构象偏好的影响。提出α-氨基的2-硝基苯基硫代发色衍生物作为肽中β-结构的圆二色性传感器。
