Weichselbaum R, Albert D M, Cassady J R, Little J B
Invest Ophthalmol Vis Sci. 1983 Jul;24(7):958-61.
In vitro x-ray survival experiments were performed on fibroblast strains derived from nine patients with sporadic unilateral retinoblastoma, 26 patients with hereditary retinoblastoma, and six normal controls. The x-ray sensitivity of the strains derived from the sporadic retinoblastoma patients and normal controls did not significantly differ from one another. The fibroblast strains derived from patients with hereditary retinoblastoma were significantly more radiosensitive to killing by x-rays as measured by clonogenic survival than either the sporadic strains or the strains derived from normal controls. We hypothesize that the increased in vitro radiosensitivity observed in some hereditary retinoblastoma strains is a reflection of an as yet uncharacterized defect in DNA or DNA replication postirradiation.
对来自9例散发性单侧视网膜母细胞瘤患者、26例遗传性视网膜母细胞瘤患者和6例正常对照的成纤维细胞系进行了体外X射线存活实验。散发性视网膜母细胞瘤患者和正常对照来源的细胞系对X射线的敏感性彼此无显著差异。通过克隆形成存活率测定，遗传性视网膜母细胞瘤患者来源的成纤维细胞系对X射线杀伤的放射敏感性明显高于散发性细胞系或正常对照来源的细胞系。我们推测，在一些遗传性视网膜母细胞瘤细胞系中观察到的体外放射敏感性增加反映了辐射后DNA或DNA复制中尚未明确的缺陷。
