Weichselbaum R R, Nove J, Little J B
Cancer Res. 1980 Mar;40(3):920-5.
The in vitro response of 53 human diploid fibroblast strains to X-irradiation was studied using a clonogenic survival assay. The strains, derived from patients with a variety of characterized clinical conditions, most with a genetic component, ranged in Do (a measure of the slope of the survival curve) from 43 to 168 rads. The mean Do's of six strains from normal individuals was 140 to 152 rads, with an overall range, based on the extremes of their standard errors, of 128 to 164 rads. Three-quarters of the strains studied fell within this range. Strains identified as sensitive came from patients with ataxia telangiectasia, progeria, the two genetic forms of retinoblastoma, and partial trisomy of chromosome 13. No marked radiosensitivity was found among strains derived from patients with a number of other conditions associated with a predisposition to malignancy.
使用克隆形成存活试验研究了53株人二倍体成纤维细胞系对X射线照射的体外反应。这些细胞系来源于患有各种已明确临床病症的患者，大多数病症具有遗传成分，其Do值（一种衡量存活曲线斜率的指标）范围为43至168拉德。来自正常个体的6个细胞系的平均Do值为140至152拉德，根据其标准误差的极值，总体范围为128至164拉德。所研究的细胞系中有四分之三落在该范围内。被鉴定为敏感的细胞系来自患有共济失调毛细血管扩张症、早老症、两种遗传性视网膜母细胞瘤以及13号染色体部分三体的患者。在来自患有许多其他与恶性肿瘤易感性相关病症的患者的细胞系中未发现明显的放射敏感性。
