Mehrotra P P, Weaver Y J, Higginbotham E A
J Am Coll Cardiol. 1983 Aug;2(2):233-9. doi: 10.1016/s0735-1097(83)80158-2.
Six patients with angina pectoris had reversible perfusion defects on stress and redistribution thallium imaging. Three patients had a positive electrocardiographic response to exercise. No significant coronary artery lesions were seen on coronary arteriography in any of the six patients. All had mild to moderate hypoxemia at rest and physiologic evidence of chronic obstructive pulmonary disease as defined by the decrease in the ratio of forced expiratory volume at 1 second to forced vital capacity (FEV1/FVC X 100) or decrease in the forced midexpiratory flow rate (FEF25-75), or both. None had clinical findings suggestive of any of the reported causes of positive thallium scans in patients with normal coronary arteriograms. Cellular dysfunction produced by hypoxemia affecting the uptake of thallium seems to be the most likely mechanism of this abnormality.
6例心绞痛患者在运动和再分布铊显像时有可逆性灌注缺损。3例患者运动时心电图反应阳性。6例患者冠状动脉造影均未发现明显冠状动脉病变。所有患者静息时均有轻至中度低氧血症，并有慢性阻塞性肺疾病的生理学证据，表现为1秒用力呼气容积与用力肺活量之比（FEV1/FVC×100）降低或用力呼气中期流速（FEF25-75）降低，或两者兼有。无一例有提示冠状动脉造影正常患者铊扫描阳性的报道病因的临床发现。低氧血症导致的细胞功能障碍影响铊的摄取似乎是这种异常最可能的机制。
