Tsukahara Y, Kotani T, Nakamura M, Fukuta T
Nihon Sanka Fujinka Gakkai Zasshi. 1983 Feb;35(2):189-93.
A case of a bizarre leiomyoblastoma (epithelioid leiomyosarcoma) which developed in the uterus of a 64-year-old woman and showed a malignant clinical course was reported. Histologically, the tumor in the present case had a number of bizarre giant cells, while the portion showing an epithelioid pattern was minor. Since the existence of an intimate inter-relationship between tumor cells and the smooth muscles of the blood vessel wall was a characteristic finding in the present case, a possible role of vascular smooth muscles as a tumorigenic matrix was suggested. Because of the closure of the internal os of the uterus by the tumor, the uterus had a cystomorphous appearance, and contained about 800ml of intrauterine fluid. The highest number of mitosis observed was 7 per 10 HPF. In view of abundant existence of intranuclear cytoplasmic inclusions, the malignancy of the present case was strongly suspected from a histological diagnostic point of view. The patient died 5 months after surgery because of metastases to the lumbar vertebra and to the lung.
报告了一例发生在一名64岁女性子宫内的奇异平滑肌瘤（上皮样平滑肌肉瘤），该病例呈现恶性临床病程。组织学上，本例肿瘤有许多奇异的巨细胞，而呈现上皮样形态的部分较少。由于肿瘤细胞与血管壁平滑肌之间存在密切的相互关系是本例的一个特征性发现，提示血管平滑肌可能作为致瘤基质发挥作用。由于肿瘤阻塞子宫内口，子宫呈囊状外观，宫腔内含有约800ml液体。观察到的最高有丝分裂数为每10个高倍视野7个。鉴于核内胞质包涵体大量存在，从组织学诊断角度强烈怀疑本例具有恶性特征。患者术后5个月因腰椎和肺部转移而死亡。
