Rathod R, Jacobs H K, Kramer N E, Rao L K, Salem M R, Towne W D
Anesthesiology. 1978 Aug;49(2):86-90. doi: 10.1097/00000542-197808000-00004.
Echocardiographic studies were made of 20 healthy patients scheduled for minor surgical procedures to determine whether this technique could be used routinely in the operating room and to evaluate the effects of halothane and enflurane on left ventricular performance. Thirteen minutes following induction of anesthesia with halothane in ten patients (mean end-tidal halothane concentration 0.93 per cent), mean arterial blood pressure, left ventricular (LV) diastolic dimension, LV fractional shortening, mean velocity of circumferential fiber shortening and systolic thickening of the posterior LV wall were significantly decreased. LV systolic dimension was increased significantly. These data indicate that halothane caused decreased contractility in the presence of a decreased afterload. Twelve minutes following induction of anesthesia with enflurane in ten patients (mean delivered enflurane concentration 2.4 per cent), mean arterial blood pressure and LV systolic and diastolic dimensions were decreased, while heart rate was increased significantly, indicating that enflurane caused vasodilatation and may have had some depressant effect on contractility. Echocardiography is a non-invasive, safe and relatively rapid method that can be used in the perioperative period to assess cardiac function and to evaluate the effects of pharmacologic agents on the heart.
对20名计划进行小型外科手术的健康患者进行了超声心动图研究，以确定该技术是否可在手术室常规使用，并评估氟烷和恩氟烷对左心室功能的影响。10名患者在使用氟烷诱导麻醉13分钟后（平均呼气末氟烷浓度0.93%），平均动脉血压、左心室（LV）舒张内径、LV缩短分数、圆周纤维缩短平均速度和左心室后壁收缩期增厚均显著降低。左心室收缩内径显著增加。这些数据表明，在存在后负荷降低的情况下，氟烷导致收缩性降低。10名患者在使用恩氟烷诱导麻醉12分钟后（平均输送恩氟烷浓度2.4%），平均动脉血压以及左心室收缩和舒张内径均降低，而心率显著增加，表明恩氟烷引起血管扩张，并且可能对收缩性有一定的抑制作用。超声心动图是一种非侵入性、安全且相对快速的方法，可用于围手术期评估心脏功能以及评估药物对心脏的影响。
