Matsuyama K, Sendo T, Yamashita C, Sugiyama K, Noda A, Iguchi S
J Pharmacobiodyn. 1983 Feb;6(2):136-8. doi: 10.1248/bpb1978.6.136.
After the intravenous administration of isoniazid (INH; 0.37 mmol/kg) or hydrazine (Hz; 0.16 mmol/kg), the minor metabolite of INH, gamma-aminobutyric acid (GABA) and Hz were measured by means of gas chromatograph-mass spectrometer (GC-MS) using deuterium labeled GABA (d2-GABA) and nitrogen fifteen labeled Hz (15N-Hz) as internal standards. In both cases, we successfully detected Hz and GABA in the brain. The brain GABA elevating effect of Hz was much higher than that of INH in spite of low dose.
静脉注射异烟肼（INH；0.37 mmol/kg）或肼（Hz；0.16 mmol/kg）后，以氘标记的γ-氨基丁酸（d2-GABA）和氮-15标记的Hz（15N-Hz）作为内标，通过气相色谱-质谱联用仪（GC-MS）测定INH的次要代谢产物γ-氨基丁酸（GABA）和Hz。在这两种情况下，我们均成功在脑中检测到Hz和GABA。尽管剂量较低，但Hz升高脑内GABA的作用远高于INH。
