Keller W J, Meyer B N, McLaughlin J L
J Pharm Sci. 1983 May;72(5):563-4. doi: 10.1002/jps.2600720523.
Combined GLC-mass spectrometry revealed that an unidentified sparteine isomer was the major component of an alkaloid extract of the aboveground portions of Lupinus argenteus Pursh. var. stenophyllus (Rydb.) Davis (Leguminosae). After isolation, this alkaloid was characterized as the least common of the known sparteine isomers, (-)-alpha-isosparteine. A preliminary pharmacological study showed (-)-alpha-isosparteine to have a more rapid onset and a shorter duration of action when compared with (-)-sparteine on rat myocardium.
气相色谱-质谱联用分析表明，一种未鉴定的鹰爪豆碱异构体是银叶羽扇豆（Lupinus argenteus Pursh. var. stenophyllus (Rydb.) Davis，豆科）地上部分生物碱提取物的主要成分。分离后，该生物碱被鉴定为已知鹰爪豆碱异构体中最不常见的(-)-α-异鹰爪豆碱。初步药理学研究表明，与(-)-鹰爪豆碱相比，(-)-α-异鹰爪豆碱对大鼠心肌的起效更快，作用持续时间更短。
