Mullin M J, Ferko A P
J Pharmacol Exp Ther. 1983 Jun;225(3):694-8.
The in vivo and in vitro effects of d-amphetamine were assessed in rats after subacute (24 hr) administration of ethanol vapor (28 mg/l). Forty-eight hours after the termination of ethanol vapor inhalation, when the animals were tolerant to the hypothermic effect of ethanol, a decreased hypothermic response to d-amphetamine was detected, suggesting that functional changes in dopaminergic activity might be associated with ethanol tolerance. The hyperthermic effect of d-amphetamine was similar in the ethanol-tolerant and control animals. The d-amphetamine-stimulated release of [3H]dopamine from crude synaptosomal (P2) fractions of striatum was nearly abolished immediately after subacute ethanol administration. Samples prepared from ethanol-tolerant animals released less [3H]dopamine in response to d-amphetamine perfusion compared to samples prepared from control animals when tested 48 hr after ethanol vapor exposure. Subacute ethanol administration appears to produce long-acting changes in d-amphetamine-sensitive dopaminergic mechanisms.
在大鼠经亚急性（24小时）给予乙醇蒸汽（28毫克/升）后，评估了右旋苯丙胺的体内和体外效应。在乙醇蒸汽吸入终止48小时后，当动物对乙醇的体温过低效应产生耐受性时，检测到对右旋苯丙胺的体温过低反应降低，这表明多巴胺能活性的功能变化可能与乙醇耐受性有关。右旋苯丙胺在乙醇耐受动物和对照动物中的体温过高效应相似。在亚急性给予乙醇后，纹状体粗突触体（P2）部分中右旋苯丙胺刺激的[3H]多巴胺释放几乎立即被消除。与在乙醇蒸汽暴露48小时后进行测试时从对照动物制备的样品相比，从乙醇耐受动物制备的样品在右旋苯丙胺灌注时释放的[3H]多巴胺较少。亚急性给予乙醇似乎会在对右旋苯丙胺敏感的多巴胺能机制中产生长效变化。
