Wittig H J, McLaughlin E T, Leifer K L, Belloit J D
Ann Allergy. 1978 Aug;41(2):84-8.
Records of 2,190 patients with demonstrable allergic disease, including 1,148 patients with asthma and 557 patients with allergic rhinitis, were analyzed for the impact of certain risk factors on age of onset of allergic disease and on sensitization to certain specific antigens. The risk factors examined included race, sex, maternal age, family structure, life style, feeding history, environmental factors and heredity of allergic disease. Age of onset was significantly earlier (P less than 0.001) in males, blacks, children of younger mothers, bottle-fed babies, children of rural origin, children of smoking parents and children with a bilateral family history of allergy.
对2190例确诊为过敏性疾病的患者记录进行了分析，这些患者包括1148例哮喘患者和557例过敏性鼻炎患者，以研究某些危险因素对过敏性疾病发病年龄以及对某些特定抗原致敏的影响。所研究的危险因素包括种族、性别、母亲年龄、家庭结构、生活方式、喂养史、环境因素以及过敏性疾病的遗传因素。男性、黑人、母亲年龄较小的儿童、人工喂养儿、来自农村的儿童、父母吸烟的儿童以及有双侧家族过敏史的儿童发病年龄显著较早（P<0.001）。
