Wong T M
Life Sci. 1983 Jul 18;33(3):255-9. doi: 10.1016/0024-3205(83)90384-3.
ADH at doses 20 microU/100 g and 100 microU/100 g or 20 microU/100 g and 200 microU/100 g was injected intravenously into pentobarbital and alcohol anaesthetized rats loaded with either water or isotonic solution consisting of NaCl, glucose and ethanol. At the dose of 20 microU/100 g ADH retained water in both water and NaCl loaded animals. At high doses 100 microU/100 g in NaCl loaded rats and 200 microU/100 g in water loaded rats, ADH retained water and increased the renal excretion of Na+. That the natriuretic effect of ADH at the dose 20 microU/100 g was enhanced in NaCl loaded rats suggests that ADH is probably important in the regulation of Na+ content in the body when it is loaded with NaCl.
将剂量为20微单位/100克和100微单位/100克或20微单位/100克和200微单位/100克的抗利尿激素静脉注射到用戊巴比妥和酒精麻醉、分别负荷水或由氯化钠、葡萄糖和乙醇组成的等渗溶液的大鼠体内。在20微单位/100克的剂量下，抗利尿激素在负荷水和负荷氯化钠的动物体内均保留水分。在高剂量下，负荷氯化钠的大鼠为100微单位/100克，负荷水的大鼠为200微单位/100克，抗利尿激素保留水分并增加钠的肾排泄。在负荷氯化钠的大鼠中，20微单位/100克剂量的抗利尿激素的利钠作用增强，这表明当机体负荷氯化钠时，抗利尿激素可能在调节体内钠含量方面起重要作用。
