Penn D, Schmidt-Sommerfeld E
Metabolism. 1983 Aug;32(8):806-9. doi: 10.1016/0026-0495(83)90111-7.
Carnitine concentrations were measured in the plasma and adipose tissue of seven chronically uremic and hyperlipidemic patients undergoing hemodialysis. Plasma levels of carnitine had dropped by the end of dialysis. The clearance of free carnitine was greater than that of acylcarnitine. Fasting plasma free carnitine, long-chain acylcarnitine, D-beta-hydroxybutyrate and free fatty acid concentrations were normal but short-chain acylcarnitine values were elevated. In adipose tissue, total carnitine concentrations were normal but long-chain acylcarnitine concentrations were increased. These findings may indicate a hypermetabolic state in which the acute removal of carnitine during hemodialysis may lead to a critical shortage of this substance.
对7名接受血液透析的慢性尿毒症和高脂血症患者的血浆和脂肪组织中的肉碱浓度进行了测量。透析结束时血浆肉碱水平下降。游离肉碱的清除率高于酰基肉碱。空腹血浆游离肉碱、长链酰基肉碱、D-β-羟基丁酸和游离脂肪酸浓度正常，但短链酰基肉碱值升高。在脂肪组织中，总肉碱浓度正常，但长链酰基肉碱浓度增加。这些发现可能表明存在一种高代谢状态，在这种状态下，血液透析期间肉碱的急性清除可能导致该物质严重短缺。
