一种参与淋巴细胞器官特异性归巢的细胞表面分子。
A cell-surface molecule involved in organ-specific homing of lymphocytes.
作者信息
Gallatin W M, Weissman I L, Butcher E C
出版信息
Nature. 1983;304(5921):30-4. doi: 10.1038/304030a0.
DOI:10.1038/304030a0
PMID:6866086
Abstract
Lymphocytes migrate from the bloodstream by recognizing and binding to specialized endothelial cells lining the high endothelial venules (HEV) in lymph nodes and Peyer's patches. We describe here a monoclonal antibody, MEL-14, specific for a lymphocyte surface molecule that appears to mediate recognition of lymph node HEV, and to be required for lymphocyte homing into lymph nodes in vivo.
摘要
淋巴细胞通过识别并结合淋巴结和派尔集合淋巴结中高内皮微静脉（HEV）内衬的特殊内皮细胞，从血液中迁移出来。我们在此描述一种单克隆抗体MEL-14，它对一种淋巴细胞表面分子具有特异性，该分子似乎介导对淋巴结HEV的识别，并且是淋巴细胞在体内归巢至淋巴结所必需的。
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