Ross R L, Kapp J P, Hochberg F, Krull I S, Ding X D, Selavka C
Neurosurgery. 1983 May;12(5):512-4. doi: 10.1227/00006123-198305000-00006.
The agent, 1,3-bis(3-chloroethyl)-1-nitrosourea (BCNU), when given by arterial infusion for brain tumor chemotherapy is usually dissolved in an alcohol/saline solution. The authors compared the osmolality of and drug recovery from solvent systems of alcohol/saline, dimethyl sulfoxide (DMSO)/water, and dextrose/water. Recovery of drug was adequate from all solvent systems, although variability of drug recovery from the alcohol/saline and DMSO/water systems was greater than from the dextrose/water system. The alcohol/saline system was significantly hyperosmolar. The alcohol/saline and DMSO/water solvent systems offer no advantage over the dextrose/water system and may be associated with significant disadvantages.
药物1,3-双（3-氯乙基）-1-亚硝基脲（卡莫司汀，BCNU）通过动脉灌注用于脑肿瘤化疗时，通常溶解于酒精/盐溶液中。作者比较了酒精/盐、二甲基亚砜（DMSO）/水和葡萄糖/水溶剂系统的渗透压及药物回收率。尽管酒精/盐和DMSO/水系统的药物回收率变异性大于葡萄糖/水系统，但所有溶剂系统的药物回收率均足够。酒精/盐系统具有显著的高渗性。酒精/盐和DMSO/水溶剂系统相比葡萄糖/水系统没有优势，且可能存在显著劣势。
