Kniazev Iu A, Nikiforova A G
Probl Endokrinol (Mosk). 1983 May-Jun;29(3):3-6.
Clinical and biochemical findings, obtained in 76 diabetic children aged 3 to 15 years, were analyzed. Osmolarity of the plasma and plasmic components (electrolytes, glucose and urine) as well as blood antidiuretic activity (ADA) were studied. Osmolarity and plasmic ADA indices increased and water-electrolyte balance deteriorated as metabolic disorders developed. No exact linear correlation between osmolarity and the blood ADA indices was observed in diabetes decompensation. A high blood ADA level is considered to be a manifestation of the pronounced organism dehydration. It was shown that blood coagulation, accumulation of active osmotic substances in the blood, i.e. glucose, urine and other products of the disordered metabolism, as well as a decrease in renal glomerular filtration cause the hyperosmolaric syndrome in diabetic children.
对76名3至15岁糖尿病儿童的临床和生化检查结果进行了分析。研究了血浆及血浆成分（电解质、葡萄糖和尿液）的渗透压以及血液抗利尿活性（ADA）。随着代谢紊乱的发展，渗透压和血浆ADA指数升高，水电解质平衡恶化。在糖尿病失代偿期，未观察到渗透压与血液ADA指数之间存在确切的线性相关性。血液ADA水平升高被认为是机体明显脱水的表现。结果表明，血液凝固、血液中活性渗透物质（即葡萄糖、尿液和其他代谢紊乱产物）的积聚以及肾小球滤过率降低导致糖尿病儿童出现高渗综合征。
