[Osmotic homeostasis and blood antidiuretic activity in diabetes mellitus in children].

Clinical and biochemical findings, obtained in 76 diabetic children aged 3 to 15 years, were analyzed. Osmolarity of the plasma and plasmic components (electrolytes, glucose and urine) as well as blood antidiuretic activity (ADA) were studied. Osmolarity and plasmic ADA indices increased and water-electrolyte balance deteriorated as metabolic disorders developed. No exact linear correlation between osmolarity and the blood ADA indices was observed in diabetes decompensation. A high blood ADA level is considered to be a manifestation of the pronounced organism dehydration. It was shown that blood coagulation, accumulation of active osmotic substances in the blood, i.e. glucose, urine and other products of the disordered metabolism, as well as a decrease in renal glomerular filtration cause the hyperosmolaric syndrome in diabetic children.