Odintsova S P, Gonikberg E M
Radiobiologiia. 1983 May-Jun;23(3):291-5.
It was shown that active radiosensitizers, nitroimidazole and nitrofuran, reduced chemically and enzymatically under anaerobic conditions in the presence of DNA, cause singlestrand breaks in the latter. When this modified DNA is exposed to ionizing radiation the yield of single-strand breaks increases as compared to control (unmodified) DNA.
研究表明，活性放射增敏剂，即硝基咪唑和硝基呋喃，在厌氧条件下于DNA存在时会发生化学和酶促还原反应，导致DNA产生单链断裂。当这种经修饰的DNA暴露于电离辐射时，与对照（未修饰）DNA相比，单链断裂的产率会增加。
