Trono D, Kapanci Y
Schweiz Med Wochenschr. 1983 May 14;113(19):701-8.
An autopsy study of 218 cases of lymphoproliferative disease was performed to establish the cause of death. It covered 144 cases of malignant nonHodgkin's lymphoma, 23 cases of Hodgkin's disease and 51 cases of myeloma. It was established that infection is by far the most frequent cause (34% of cases) followed by tumor invasion (11.5% of cases), hemorrhage (9% of cases) and other pathologies linked to the basic process (10% of cases). The proportion of patients who die from intercurrent illness is still considerable (62 cases, 28%). Infection is most often pulmonary or systemic; gram-negative bacteria play a predominant role. Toxicity of treatment is obvious in causing neutropenia and thrombocytopenia among other side effects with fatal consequences.
对218例淋巴增生性疾病患者进行了尸检研究以确定死因。其中包括144例恶性非霍奇金淋巴瘤、23例霍奇金病和51例骨髓瘤。结果表明，感染是迄今为止最常见的死因（占病例的34%），其次是肿瘤侵袭（占病例的11.5%）、出血（占病例的9%）以及与基础疾病相关的其他病理情况（占病例的10%）。死于并发疾病的患者比例仍然相当可观（62例，占28%）。感染最常见于肺部或全身性；革兰氏阴性菌起主要作用。治疗的毒性在导致中性粒细胞减少和血小板减少等副作用方面很明显，这些副作用会带来致命后果。
