Bersu E T, Crandell C, White B J
Teratology. 1983 Apr;27(2):271-6. doi: 10.1002/tera.1420270215.
Changes in the type, size, and relative percentage of different erythrocyte populations in the peripheral blood of individual trisomy 19 and normal littermate mouse fetuses were studied from 12 gestational days to term. Large nucleated erythrocytes of yolk-sac origin comprise the first population of cells and are gradually diluted out of the circulation by nonnucleated erythrocytes of hepatic origin. This transition occurs between 12 and 16 gestational days. The rate of decline of the nucleated erythrocytes in the trisomic animals lagged by approximately 1 day behind the normal littermates, so that they did not completely disappear from the peripheral circulation until day 17. A slight decrease in size of the nonnucleated erythrocytes which occurs with increasing gestational age was also delayed by approximately 1 day in the trisomic fetuses. These observations are consistent with an hypothesis that one effect of the murine trisomy 19 genome is to retard by 1 day the growth and development of the affected animal.
研究了19号染色体三体的个体小鼠胎儿及正常同窝小鼠胎儿从妊娠第12天到足月时外周血中不同红细胞群体的类型、大小和相对百分比的变化。卵黄囊来源的有核大红细胞是最早出现的细胞群体，并逐渐被肝脏来源的无核红细胞挤出循环。这种转变发生在妊娠第12天到16天之间。三体动物中有核红细胞的下降速度比正常同窝小鼠滞后约1天，因此它们直到第17天才从外周循环中完全消失。随着胎龄增加，无核红细胞大小略有减小，这一现象在三体胎儿中也延迟了约1天。这些观察结果与一个假说相符，即小鼠19号染色体三体基因组的一个作用是使受影响动物的生长和发育延迟1天。
