Ugarova T P, Lugovskoĭ E V, Gorkun O V, Derzskaia S G
Ukr Biokhim Zh (1978). 1983;55(3):254-9.
Intermediate fibrin polymers formed from fibrinogen at low thrombin concentrations under physiological conditions are studied for their stability. Smith's statement that intermediate fibrin oligomers are inert molecules whose further self-assembly is possible only under additional thrombin activation was not supported. It is shown that the intermediate fibrin polymer stability at pH 7.4 is not high because of a strong tendency to aggregation and the higher molecular weight of the polymer the less its stability. The polymer stability in solution increases with pH. Stability of soluble fibrin complexes in solution depends on their size, defined by environmental conditions and on the quantity of fibrinogen present.
研究了在生理条件下低凝血酶浓度时由纤维蛋白原形成的中间纤维蛋白聚合物的稳定性。史密斯认为中间纤维蛋白寡聚体是惰性分子，只有在额外的凝血酶激活下才可能进一步自组装，这一观点未得到支持。结果表明，由于强烈的聚集倾向，pH 7.4时中间纤维蛋白聚合物的稳定性不高，且聚合物分子量越高，其稳定性越低。溶液中聚合物的稳定性随pH升高而增加。溶液中可溶性纤维蛋白复合物的稳定性取决于其大小（由环境条件决定）以及存在的纤维蛋白原数量。
