Demaurex A, Küng H L, Wirz H
Soz Praventivmed. 1983;28(2):88-94.
Creatinine and density of urine as reference parameters in biological monitoring Since in practice biological monitoring with 24-hour urine samples is not possible, a reference parameter is required. In two different experimental models - for 10 days in 24-hour portions and for 1 day with spontaneous individual fractions - creatinine excretion, mean daily urine volume and urine density were measured quantitatively in 5 healthy human subjects not exposed to chemistry. In the 10-day model, coefficients of variation were: 8.7% for creatinine, 24.9% for mean urine volume and 11.7% for urine density. In the 1-day model, coefficients of variation were: 15.8% for creatinine, 51.0% for mean urine volume and 28.0% for density. This indicates that the results of the second model are considerably more expressive than those of the first. It can be concluded that creatinine is the most suitable reference parameter. Density is less suitable and mean urine volume least suitable.
肌酐和尿密度作为生物监测的参考参数 由于在实际操作中不可能采用24小时尿液样本进行生物监测，因此需要一个参考参数。在两个不同的实验模型中——一个是将24小时尿液分份进行为期10天的实验，另一个是对自发的个体尿液分份进行为期1天的实验——对5名未接触化学物质的健康人类受试者的肌酐排泄量、日均尿量和尿密度进行了定量测量。在为期10天的模型中，变异系数分别为：肌酐8.7%，平均尿量24.9%，尿密度11.7%。在为期1天的模型中，变异系数分别为：肌酐15.8%，平均尿量51.0%，密度28.0%。这表明第二个模型的结果比第一个模型的结果更具代表性。可以得出结论，肌酐是最合适的参考参数。密度不太合适，平均尿量最不合适。
