Ito H, Tahara E
Acta Pathol Jpn. 1983 Mar;33(2):287-96. doi: 10.1111/j.1440-1827.1983.tb01418.x.
A total of 164 gastric carcinomas comprising 97 advanced cancers and 67 early cancers were examined immunohistochemically for human chorionic gonadotropin (hCG). Tumor cells containing immunoreactive hCG was found in 7 cases or 10.4% of the early cancer cases and in 11 cases or 11.3% of the advanced cancer cases. Moreover, the incidence of hCG-beta subunit positive cells was 8.2% in the advanced cancer cases and 6.0% in the early cancer cases. The incidence of these cells did not differ significantly by histological type and by infiltrative growth of gastric carcinoma. However, hCG-containing tumor cells were frequently detected in poorly differentiated or undifferentiated area within the tumor. In addition, these cells did not contain mucin or argyrophil granules. The three year survival rates indicated a tendency for advanced gastric cancer containing hCG to have a poor prognosis.
对总共164例胃癌进行了免疫组织化学检查，其中包括97例进展期癌和67例早期癌，检测人绒毛膜促性腺激素（hCG）。在7例（占早期癌病例的10.4%）早期癌病例和11例（占进展期癌病例的11.3%）进展期癌病例中发现了含有免疫反应性hCG的肿瘤细胞。此外，hCG-β亚基阳性细胞的发生率在进展期癌病例中为8.2%，在早期癌病例中为6.0%。这些细胞的发生率在组织学类型和胃癌浸润性生长方面无显著差异。然而，在肿瘤内分化差或未分化区域经常检测到含hCG的肿瘤细胞。此外，这些细胞不含黏液或嗜银颗粒。三年生存率表明，含有hCG的进展期胃癌预后较差。
