牛用土霉素。常规制剂与长效制剂的比较。
Oxytetracyclines in cattle. A comparison between a conventional and a long-acting preparation.
作者信息
Xia W, Nielsen P, Gyrd-Hansen N
出版信息
Acta Vet Scand. 1983;24(1):120-8. doi: 10.1186/BF03546763.
Abstract
Pharmacokinetics of oxytetracycline (OTC) were studied in 4 cows after administration of either a conventional (OTC-C) or a long-acting (OTC-LA) preparation. After intravenous administration of OTG-G the elimination half-life for OTG was found to be 6 h. Intramuscular injection of OTC-C and OTC-LA resulted in almost identical plasma concentrations of OTC with peak values after 6–8 h. For both preparations the bioavailability after i.m. administration was 100 % and about 60 of the dose was excreted in the urine during the first week. Plasma concentrations above 0.5 μg/ml were with both preparations maintained for approximately 60 h, indicating no retard effect of OTC-LA as compared to OTC-C.
摘要
在4头奶牛中研究了土霉素（OTC）的药代动力学，分别给予常规制剂（OTC-C）或长效制剂（OTC-LA）。静脉注射土霉素葡萄糖酸盐（OTG-G）后，发现OTG的消除半衰期为6小时。肌肉注射OTC-C和OTC-LA导致OTC的血浆浓度几乎相同，在6-8小时后达到峰值。对于这两种制剂，肌肉注射后的生物利用度均为100%，并且在第一周内约60%的剂量经尿液排出。两种制剂的血浆浓度在0.5μg/ml以上均维持约60小时，表明与OTC-C相比，OTC-LA没有延迟作用。
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