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[关于在儿童重症监护病房接受治疗的新生儿的未来的调查。三、神经异常]

[Inquiry on the future of newborns treated in intensive care units for children. III. Neurologic anomalies].

作者信息

Lalande J, Le Loc'h H, Doyon F

出版信息

Arch Fr Pediatr. 1978 Apr;35(4):351-65.

PMID:686947
Abstract

This study concerned newborns admitted between 0 and 10 days of life at the intensive care unit of the Hospital St-Vincent-de-Paul from 1969 to 1972. They were followed later as outpatients. Out of 1,607 newborns admitted, 1,126 survived (average mortality: 30%). 532 were examined after one year, 397 after two years. On the whole prognosis may be considered as good: at 2 years of age, 8% had major neurologic abnormalities; 4% minor abnormalities, no increase in the percentage of major neurologic abnormalities between 1969 (6%) and 1972 (5%), whereas mortality decreased from 36 to 24%. The various types of neurologic deficits were analyzed, according to their effects on rehabilitation (4% had severe retardation, 11% moderate retardation). The sensory involvement (3%) and intercurrent seizures (10%) were also analyzed. According to the bias of the Unit in recruitment, this enquiry concerned children close from term or medium premature children (B.W. 1,500 g) : this diminishes the true rate of the neurologic deficit. The relationships between etiology of neonatal distress and delayed neurologic abnormalities are emphasized.

摘要

本研究关注1969年至1972年期间在圣文森特 - 德保罗医院重症监护病房出生后0至10天内入院的新生儿。他们后来作为门诊病人接受随访。在1607名入院新生儿中,1126名存活(平均死亡率:30%)。532名在1年后接受检查,397名在2年后接受检查。总体而言,预后可被认为良好:在2岁时,8%有严重神经异常;4%有轻微异常,1969年(6%)至1972年(5%)期间严重神经异常的百分比没有增加,而死亡率从36%降至24%。根据对康复的影响分析了各种类型的神经缺陷(4%有严重发育迟缓,11%有中度发育迟缓)。还分析了感觉障碍(3%)和间发性癫痫(10%)。根据该病房在招募方面的偏向,本调查涉及接近足月或中度早产的儿童(体重1500克):这降低了神经缺陷的真实发生率。强调了新生儿窘迫病因与延迟性神经异常之间的关系。

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