急性病毒性肝炎并发肝昏迷时弥散性血管内凝血的研究。

A study of disseminated intravascular coagulopathy in hepatic coma complicating acute viral hepatitis.

作者信息

Singh R, Singh M M, Hazra D K, Agarwal N, Patney N L, Goyal S P, Bansal O P, Mehrotra M P, Sharma S K

出版信息

Angiology. 1983 Jul;34(7):470-9. doi: 10.1177/000331978303400707.

DOI:10.1177/000331978303400707

Abstract

Thirty cases of viral hepatitis with and without coma and 15 normal healthy age and sex matched controls were studied for disseminated intravascular coagulopathy (DIC). Cases of viral hepatitis with coma showed strong evidence of DIC in the form of increased plasma FDP (240 +/- 190.64 dilution), diminished fibrinogen half life (48.1 +/- 15.3 hours) and increased fractional catabolic rate (46.13 +/- 14.7% per day) with normal Euglobulin clot lysis time and reduced fibrinogen (147.33 +/- 43.5%) and platelet count (1.27 +/- 0.324 lakhs/cm.). The possible role of heparin in the reversal of coagulation abnormalities have been discussed.

摘要

对30例伴有或不伴有昏迷的病毒性肝炎患者以及15名年龄和性别相匹配的正常健康对照者进行了弥散性血管内凝血（DIC）研究。伴有昏迷的病毒性肝炎患者表现出明显的DIC证据，表现为血浆纤维蛋白降解产物（FDP）增加（240±190.64稀释度）、纤维蛋白原半衰期缩短（48.1±15.3小时）、分数分解代谢率增加（每天46.13±14.7%），优球蛋白凝块溶解时间正常，纤维蛋白原减少（147.33±43.5%）以及血小板计数减少（1.27±0.324万/cm³）。文中还讨论了肝素在逆转凝血异常方面的可能作用。