Smith J A, Mansfield L E, Fokakis A, Nelson H S
Ann Allergy. 1983 Jul;51(1 Pt 1):30-2.
A patient developed symptomatic dermographia while taking penicillin. The dermographia disappeared when the penicillin was stopped. The patient usually was negative for dermographia testing up to 400 g pressure. While taking penicillin a dermographic response occurred at 50 g pressure. Passive transfer skin testing established that the reaction was mediated by an IgE antibody to penicillin breakdown products. Interestingly, in both the subject and the passive transfer recipient skin testing to Pen G, M.D.M. and B.P.L. was negative. We concluded that the dermographia in our patient resulted from specific IgE penicillin interactions not recognized by the usual testing reagents.
一名患者在服用青霉素时出现了症状性皮肤划痕症。停用青霉素后，皮肤划痕症消失。该患者在高达400克压力的皮肤划痕症测试中通常为阴性。服用青霉素期间，在50克压力时出现了皮肤划痕反应。被动转移皮肤试验证实，该反应由针对青霉素降解产物的IgE抗体介导。有趣的是，该患者以及被动转移受体对青霉素G、M.D.M.和B.P.L.的皮肤试验均为阴性。我们得出结论，该患者的皮肤划痕症是由普通检测试剂未识别的特异性IgE与青霉素相互作用引起的。
