Gentry P A, Cooper M L
Am J Vet Res. 1983 May;44(5):741-6.
The single IV administration of T-2 toxin to calves at a dosage of 0.25 mg/kg of body weight produced statistically significant decreases in plasma activity of factors VII, IX, X, and XI and in fibrinogen values (P less than 0.05). Similar changes in the coagulation factors were observed after the single IV administration of T-2 toxin to calves which were given vitamin K (25 mg daily) for 5 days before and after dosing with T-2 toxin. The procoagulant activity of factor VIII was unaffected by T-2 toxin administration to calves.
以0.25毫克/千克体重的剂量给犊牛单次静脉注射T-2毒素后，凝血因子VII、IX、X和XI的血浆活性以及纤维蛋白原值出现了具有统计学意义的下降（P小于0.05）。在给犊牛单次静脉注射T-2毒素之前和之后连续5天给予维生素K（每日25毫克）的情况下，对犊牛注射T-2毒素后观察到了凝血因子的类似变化。给犊牛注射T-2毒素未影响因子VIII的促凝血活性。
