Nikonov A A, Veresh I
Arkh Patol. 1978;40(6):63-6.
A description of malignant carcinoid of alveolartrabecular structure developing in the edge of chronic progressive gastric ulcer is presented. Granules detectable by argirophilic method of Grimelius, toluidine blue after acid hydrolysis, and lead hemotoxylin were found in the cytoplasm of tumor cells. Changes in the epithelium of the type of cancer in situ as well as marked hyperplasia of argirophilic cells were observed in gastric mucosa in the edges of the ulcer. Although this observation may be interpreted as a peculiar variant of Zollinger-Ellison syndrome, it is more likely that this is a malignized chronic ulcer with carcinoid differentiation of the tumor tissue.
本文描述了在慢性进行性胃溃疡边缘发生的具有肺泡小梁结构的恶性类癌。在肿瘤细胞的细胞质中发现了用Grimelius嗜银法、酸水解后的甲苯胺蓝以及铅苏木精可检测到的颗粒。在溃疡边缘的胃黏膜中观察到原位癌类型的上皮细胞变化以及嗜银细胞的明显增生。尽管这一观察结果可能被解释为佐林格-埃利森综合征的一种特殊变体，但更有可能的是，这是一种肿瘤组织具有类癌分化的恶性慢性溃疡。
