庆大霉素在人体受试者中的鼻内给药。
Intranasal administration of gentamicin in human subjects.
作者信息
Rubinstein A
出版信息
Antimicrob Agents Chemother. 1983 May;23(5):778-9. doi: 10.1128/AAC.23.5.778.
Abstract
The effectiveness of gentamicin administered by the intranasal route in healthy human volunteers was studied. Thirty minutes after gentamicin in a solution of 1% sodium glycocholate was administered at 2 mg/kg of body weight, gentamicin concentrations of 2.48 +/- 0.42 mg/ml were present in the sera. Serum concentrations decreased to 0.94 +/- 0.13 mg/ml at 180 min. No serious side effects were observed. There was slight local irritation after a single dose. When administered intranasally without glycocholate, gentamicin was not present in the sera in detectable amounts.
摘要
研究了庆大霉素经鼻内途径给药对健康人类志愿者的有效性。在以2mg/kg体重给予1%甘氨胆酸钠溶液中的庆大霉素30分钟后，血清中庆大霉素浓度为2.48±0.42mg/ml。180分钟时血清浓度降至0.94±0.13mg/ml。未观察到严重副作用。单次给药后有轻微局部刺激。在无甘氨胆酸钠经鼻内给药时，血清中未检测到庆大霉素。
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本文引用的文献
1
Increase of the intestinal absorption of gentamicin and amikacin by a nonionic surfactant.
Antimicrob Agents Chemother. 1981 May;19(5):696-9. doi: 10.1128/AAC.19.5.696.
2
Insulin given intranasally induces hypoglycaemia in normal and diabetic subjects.
Br Med J (Clin Res Ed). 1982 Jan 30;284(6312):303-6. doi: 10.1136/bmj.284.6312.303.
3
Effective intestinal absorption of insulin in diabetic rats using a new formulation approach.
J Pharm Pharmacol. 1980 Feb;32(2):108-10. doi: 10.1111/j.2042-7158.1980.tb12863.x.
4
Rapid microassay of gentamicin, kanamycin, neomycin, streptomycin, and vancomycin in serum or plasma.
J Lab Clin Med. 1971 Sep;78(3):457-63.
5
Mechanisms of surfactant effects on drug absorption.
J Pharm Sci. 1970 May;59(5):579-89. doi: 10.1002/jps.2600590502.
6
New hydrophilic vehicle enabling rectal and vaginal absorption of insulin, heparin, phenol red and gentamicin.
J Pharm Pharmacol. 1978 Oct;30(10):662-3. doi: 10.1111/j.2042-7158.1978.tb13356.x.
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