Brooke M M, Donovon W H, Stolov W C
Arch Phys Med Rehabil. 1978 Jul;59(7):306-9.
The rapid development of hyperkalemia leading to cardiac arrest can occur in patients with spinal cord injuries and other conditions when succinylcholine is used during the induction of anesthesia. Three patients with thoracolumbar spinal cord injuries resulting in lower motor neuron lesions or lesions above the lower extremity motor units developed hyperkalemia followed by cardiac arrest after succinylcholine administration. The mechanism by which succinylcholine leads to hyperkalemia from denervated muscle is described and precautions to be taken are mentioned. Physicians caring for patients with denervated muscle due to spinal cord injuries should be aware of this danger and nondepolarizing muscle relaxants should be used instead of succinylcholine.
在脊髓损伤及其他病症患者中，麻醉诱导期使用琥珀酰胆碱时，可迅速发生高钾血症并导致心脏骤停。三名胸腰段脊髓损伤导致下运动神经元损伤或下肢运动单位以上部位损伤的患者，在给予琥珀酰胆碱后出现高钾血症，随后发生心脏骤停。文中描述了琥珀酰胆碱导致去神经肌肉出现高钾血症的机制，并提及了应采取的预防措施。护理因脊髓损伤而有去神经肌肉的患者的医生应意识到这种危险，应使用非去极化肌松药而非琥珀酰胆碱。
