Emura I, Sekiya M, Ohnishi Y
Arch Histol Jpn. 1983 Feb;46(1):103-14. doi: 10.1679/aohc.46.103.
Megakaryocytes in the liver obtained from 185 human embryos and fetuses during the period from 28 days to 22 weeks of ovulation were investigated by light and electron microscopy. The early hepatic megakaryoblasts and the early hepatic promegakaryocytes at stage I observed in the intercellular spaces of the hepatocytes until 10 weeks of ovulation (early stage of hepatic hemopoiesis) were larger than the late hepatic megakaryoblasts and the late hepatic promegakaryocytes at stage I observed after 10 weeks of ovulation (late stage of hepatic hemopoiesis). The chromatin of the former two cells was finely dispersed, whereas that of the latter two showed moderate central and peripheral clumping. These findings seem to indicate that the progenitor cells of the magakaryoblasts and the hemopoietic stem cells in the liver in the early stage of hepatic hemopoiesis morphologically differ from those in the liver in the late stage, and that the megakaryocytes in the liver until 10 weeks of ovulation differ in maturation course from those after this ovulation stage.
对185例排卵后28天至22周的人胚胎和胎儿肝脏中的巨核细胞进行了光镜和电镜研究。在排卵后10周（肝脏造血早期）观察到的位于肝细胞间隙中的早期肝原巨核细胞和I期早期肝前巨核细胞，比排卵后10周（肝脏造血后期）观察到的晚期肝原巨核细胞和I期晚期肝前巨核细胞大。前两种细胞的染色质分散良好，而后两种细胞的染色质则显示出中度的中央和周边聚集。这些发现似乎表明，肝脏造血早期的原巨核细胞祖细胞和造血干细胞在形态上与肝脏造血后期的不同，并且排卵后10周内肝脏中的巨核细胞在成熟过程上与该排卵阶段后的不同。
