Terce F, Tocanne J F, Laneelle G
Biochem Pharmacol. 1983 Jul 15;32(14):2189-94. doi: 10.1016/0006-2952(83)90225-3.
The modification of certain membrane properties by ellipticine derivatives was examined. The amphiphilic 9-methoxyellipticine was the most efficient in disorganizing membrane structure and in inducing leaks of liposomes, haemolysis of intact human erythrocytes. This drug and the dipolar 9-amino- and 9-hydroxyellipticine were equally efficient in decreasing the surface charge of membranes and in inhibiting the respiration of an isolated bacterial membrane.
