Barbui T, Finazzi G, Rodeghiero F, Dini E
Br J Haematol. 1983 Aug;54(4):561-5. doi: 10.1111/j.1365-2141.1983.tb02134.x.
An Italian family with thrombosis and hereditary dysfunctional AT III, i.e. reduced biological activity and normal levels of the immunoreactive protein is presented. The abnormal molecule, called AT III 'Vicenza', was characterized by two-dimensional crossed immunoelectrophoresis either in the absence or presence of heparin. In the presence of heparin, a normal pattern was found in plasma, but abnormality was evident in serum. A similar abnormality was found in plasma artificially clotted with thrombin. The role of thrombin in inducing the immunoelectrophoretic abnormality of AT III 'Vicenza' is discussed.
本文介绍了一个患有血栓形成和遗传性抗凝血酶III功能障碍的意大利家庭，即免疫反应性蛋白水平正常但生物活性降低。这种异常分子被称为抗凝血酶III“维琴察”，通过二维交叉免疫电泳在有无肝素的情况下进行了表征。在有肝素存在的情况下，血浆中发现了正常模式，但血清中则明显异常。在用凝血酶人工凝结的血浆中也发现了类似的异常。讨论了凝血酶在诱导抗凝血酶III“维琴察”免疫电泳异常中的作用。
