两性霉素B对3T3细胞中亮氨酸摄取的影响。
Influence of amphotericin B on leucine uptake in 3T3 cells.
作者信息
Foresti M, Amati P
出版信息
Biochim Biophys Acta. 1983 Jul 13;732(1):251-5. doi: 10.1016/0005-2736(83)90209-2.
PMID:6871192
Abstract
By studying the effect of leucine competitors we found that activation of the specific leucine-transport system underlies the enhancement of leucine uptake in mouse 3T3 fibroblast cells induced by sublethal doses of Amphotericin B (synergic effect). The relation of the antibiotic activity and the alteration of the membrane cholesterol interaction with lipids is discussed.
摘要
通过研究亮氨酸竞争剂的作用，我们发现特定亮氨酸转运系统的激活是亚致死剂量两性霉素B诱导小鼠3T3成纤维细胞中亮氨酸摄取增强（协同效应）的基础。本文还讨论了抗生素活性与膜胆固醇与脂质相互作用改变之间的关系。
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