急性和慢性给予氟哌啶醇对大鼠黑质纹状体及视网膜多巴胺能神经元中多巴胺代谢的不同影响。

Differential effect of acute and chronic haloperidol administration on dopamine turnover in rat nigrostriatal and retinal dopaminergic neurons.

作者信息

Melamed E, Durst R, Frucht Y, Globus M

出版信息

Eur J Pharmacol. 1983 May 6;89(3-4):279-82. doi: 10.1016/0014-2999(83)90506-x.

Abstract

Haloperidol-induced increases in DOPAC and HVA declined in the striatum but remained unchanged in the retina after chronic pretreatment with haloperidol (1-4 weeks). DA concentrations were unaffected in the striatum but decreased in the retina after acute or chronic haloperidol administration. Light stimulation increased both retinal DA and DOPAC. The findings indicate that acute and chronic haloperidol affect nigrostriatal and retinal DA neurons differentially. In addition, DA neurons in retina respond differently to activations by haloperidol and light.

摘要

在使用氟哌啶醇（1 - 4周）进行慢性预处理后，氟哌啶醇诱导的纹状体中3,4-二羟基苯乙酸（DOPAC）和高香草酸（HVA）的增加有所下降，但视网膜中的这些指标保持不变。急性或慢性给予氟哌啶醇后，纹状体中的多巴胺（DA）浓度未受影响，但视网膜中的DA浓度降低。光刺激可增加视网膜中的DA和DOPAC。这些发现表明，急性和慢性氟哌啶醇对黑质纹状体和视网膜DA神经元的影响存在差异。此外，视网膜中的DA神经元对氟哌啶醇和光激活的反应也不同。