Walter S J, Shirley D G
Eur J Pharmacol. 1983 May 6;89(3-4):283-6. doi: 10.1016/0014-2999(83)90507-1.
A sodium deficit was induced in Brattleboro rats by lowering the dietary sodium content. Urine volume was only slightly reduced. Addition of hydrochlorothiazide to the food caused a small, transient sodium deficit but led to a marked, sustained antidiuresis. The acute administration of a large dose of hydrochlorothiazide produced a larger, sustained sodium deficit but no lasting antidiuresis. These results indicate that sodium depletion cannot account for the antidiuresis of hydrochlorothiazide treatment in diabetes insipidus.
通过降低饮食中的钠含量，在布拉特洛维大鼠中诱发了钠缺乏。尿量仅略有减少。在食物中添加氢氯噻嗪会导致轻微的、短暂的钠缺乏，但会导致明显的、持续的抗利尿作用。急性给予大剂量氢氯噻嗪会产生更大的、持续的钠缺乏，但不会产生持久的抗利尿作用。这些结果表明，钠耗竭不能解释氢氯噻嗪治疗尿崩症时的抗利尿作用。
