Erdreich A, Spanier R, Rahamimoff H
Eur J Pharmacol. 1983 Jun 3;90(2-3):193-202. doi: 10.1016/0014-2999(83)90237-6.
This study on the effect of verapamil on the Na+-dependent Ca2+ uptake system (Na+-Ca2+ exchanger) of synaptic plasma membrane (SPM) vesicles showed that verapamil inhibited the Na+-dependent Ca2+ uptake in a dose dependent manner. A 50% inhibition was obtained with 175 microM verapamil. Calcium uptake in SPM vesicles is dependent on the Na+ gradient across the membrane and on the membrane potential. Both components of the Ca2+ uptake system were inhibited by verapamil. Na+-coupled GABA uptake in SPM vesicles was also inhibited by verapamil in a similar dose-dependent fashion. It seems therefore that verapamil inhibits Na+ gradient driven processes in synaptic plasma membrane vesicles.
这项关于维拉帕米对突触质膜（SPM）囊泡的钠依赖性钙摄取系统（钠钙交换体）影响的研究表明，维拉帕米以剂量依赖性方式抑制钠依赖性钙摄取。175微摩尔的维拉帕米可产生50%的抑制作用。SPM囊泡中的钙摄取取决于跨膜钠梯度和膜电位。钙摄取系统的这两个组成部分均被维拉帕米抑制。SPM囊泡中钠偶联的γ-氨基丁酸摄取也被维拉帕米以类似的剂量依赖性方式抑制。因此，维拉帕米似乎抑制突触质膜囊泡中由钠梯度驱动的过程。
