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与尼莫地平和硝苯地平相比，新型钙通道阻滞剂FR 34235对兔基底动脉去甲肾上腺素、钾离子和5-羟色胺收缩反应的抑制作用。

The inhibitory action of FR 34235 (a new Ca2+ entry blocker) as compared to nimodipine and nifedipine on the contractile response to norepinephrine, potassium and 5-hydroxytryptamine in rabbit basilar artery.

作者信息

Takagi T, Satake N, Shibata S

出版信息

Eur J Pharmacol. 1983 Jun 3;90(2-3):297-9. doi: 10.1016/0014-2999(83)90254-6.

DOI:10.1016/0014-2999(83)90254-6
PMID:6873189
Abstract

In isolated basilar arteries, FR 34235 (FR), a new Ca2+ entry blocker, inhibited the contractile response to potassium, norepinephrine and 5-hydroxytryptamine (5-HT) in a dose-dependent manner. The potency of the inhibitory action of FR was in the following order: potassium greater than 5-HT greater than norepinephrine. Nifedipine had a similar inhibitory action on the responses. Nimodipine had no inhibitory effect on the response to norepinephrine but suppressed the responses to potassium and 5-HT.

摘要

在离体基底动脉中，新型钙通道阻滞剂FR 34235（FR）以剂量依赖性方式抑制对钾、去甲肾上腺素和5-羟色胺（5-HT）的收缩反应。FR的抑制作用强度顺序如下：钾＞5-HT＞去甲肾上腺素。硝苯地平对这些反应有类似的抑制作用。尼莫地平对去甲肾上腺素的反应无抑制作用，但可抑制对钾和5-HT的反应。

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