卫星细胞和胚胎成肌细胞对肿瘤启动子的差异反应。

Differential response of satellite cells and embryonic myoblasts to a tumor promoter.

作者信息

Cossu G, Molinaro M, Pacifici M

出版信息

Dev Biol. 1983 Aug;98(2):520-4. doi: 10.1016/0012-1606(83)90382-2.

Abstract

Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) reversibly suppressed myotube formation and expression of acetylcholine receptors in cultures of Day 15 mouse embryo presumptive myoblasts, but was totally ineffective in cultures of adult mouse satellite cells. A subpopulation of TPA-resistant myogenic cells became apparent in cultures prepared from older embryos or newborn mice. Thus, limb presumptive myoblasts are a heterogeneous population, and part of the distinct TPA-resistant subpopulation may represent satellite cell precursors.

摘要

用12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯（TPA）处理可逆转第15天小鼠胚胎推定成肌细胞培养物中的肌管形成和乙酰胆碱受体的表达，但对成年小鼠卫星细胞培养物完全无效。在从较老胚胎或新生小鼠制备的培养物中，TPA抗性肌源性细胞亚群变得明显。因此，肢体推定成肌细胞是一个异质群体，不同的TPA抗性亚群的一部分可能代表卫星细胞前体。