Department of Neurology and Neurological Sciences, Stanford University, School of Medicine, Stanford, CA 94305-5235, USA.
Semin Cell Dev Biol. 2010 Oct;21(8):845-54. doi: 10.1016/j.semcdb.2010.09.003. Epub 2010 Sep 19.
Satellite cells, the adult stem cells responsible for skeletal muscle regeneration, are defined by their location between the basal lamina and the fiber sarcolemma. Increasing evidence suggests that satellite cells represent a heterogeneous population of cells with distinct embryological origin and multiple levels of biochemical and functional diversity. This review focuses on the rich diversity of the satellite cell population based on studies across species. Ultimately, a more complete characterization of the heterogeneity of satellite cells will be essential to understand the functional significance in terms of muscle growth, homeostasis, tissue repair, and aging.
卫星细胞是负责骨骼肌再生的成体干细胞，其特征在于它们位于基底膜和纤维肌膜之间。越来越多的证据表明，卫星细胞代表了一个具有不同胚胎起源和多个生化和功能多样性水平的异质性细胞群体。本综述基于跨物种的研究，重点介绍了卫星细胞群体的丰富多样性。最终，更全面地表征卫星细胞的异质性对于理解其在肌肉生长、稳态、组织修复和衰老方面的功能意义至关重要。
