Robien W, Zolle I
Int J Appl Radiat Isot. 1983 Jun;34(6):907-14. doi: 10.1016/0020-708x(83)90153-9.
Metyrapone has been labelled with radioiodine selectively in the 4'-position of ring B. The synthesis of 123I-(131)-metyrapone involves four intermediate compounds. 4'-Bromo-metyrapone serves as a stable precursor that is labelled before use. Studies of the biodistribution of [131I]metyrapone in rats indicate the highest concentration in the adrenal gland 10 min after the injection with a fast elimination of the radioactivity. However, the absolute uptake in the normal adrenal is low. When [123I]metyrapone was used in a patient with bilateral hyperplasia, faint adrenal images were obtained.
甲吡酮已被放射性碘选择性标记在B环的4'-位。123I-（131）-甲吡酮的合成涉及四种中间化合物。4'-溴-甲吡酮作为一种稳定的前体，在使用前进行标记。[131I]甲吡酮在大鼠体内的生物分布研究表明，注射后10分钟肾上腺中的浓度最高，放射性快速消除。然而，正常肾上腺的绝对摄取量较低。当[123I]甲吡酮用于双侧增生患者时，获得的肾上腺影像较淡。
