van Dijk J P, van Kreel B K, Heeren J W
J Dev Physiol. 1983 Jun;5(3):195-207.
The interrelationship between fetal iron uptake and maternal iron metabolism has been studied in the guinea pig in the course of pregnancy. The rapid increase of the maternal need for iron during the period of fast increasing rates of placental iron transfer is largely compensated for by increased intestinal absorption. No enhanced mobilisation of iron from the liver and spleen iron stores could be demonstrated. The plasma iron turnover, corrected for the transplacental iron transfer rate, remained constant during pregnancy. This means that not only the mobilisation of iron from the stores remains principally unchanged, but also the supply of iron to the maternal organs and tissues. The haemoglobin concentration decreased by about 15% during the period of rapid fetal growth and iron uptake. The maternal blood volume increased during this very period and explained most of the observed reduction. Intestinal iron absorption increases. At day 55 of pregnancy placental iron transfer is maximal. It could be shown that a day 55 the rate of intestinal iron uptake equals the rate of iron transfer across the placentas. It is evident that pregnancy effects a direct influence on intestinal iron absorption, independent of the magnitude of the maternal iron stores. How this influence is realized without changing the iron kinetics of the maternal stores, cannot be explained with the prevailing theory.
在豚鼠孕期研究了胎儿铁摄取与母体铁代谢之间的相互关系。在胎盘铁转运速率快速增加的时期，母体对铁需求的迅速增加在很大程度上通过肠道吸收增加得到补偿。未显示肝脏和脾脏铁储备中铁的动员增强。校正经胎盘铁转运速率后的血浆铁周转率在孕期保持恒定。这意味着不仅储存铁的动员基本保持不变，而且向母体器官和组织的铁供应也保持不变。在胎儿快速生长和铁摄取期间，血红蛋白浓度下降约15%。在此期间母体血容量增加，这解释了观察到的大部分下降。肠道铁吸收增加。在妊娠第55天时胎盘铁转运最大。可以表明，在妊娠第55天时肠道铁摄取速率等于跨胎盘的铁转运速率。显然，妊娠对肠道铁吸收有直接影响，与母体铁储备量无关。这种影响如何在不改变母体储备铁动力学的情况下实现，用现有理论无法解释。
