Nadalini V F, Giglio C, Bruttini G, Positano N, Fassone M, Fasce L, Medica M, de Angelis P, Fantacci O, Scarpati D, Ledda S
J Urol (Paris). 1983;89(3):187-190.
The authors report a preliminary study of 12 cases of carcinoma of the prostate confined to the prostate (T1, T2, T3, NO, MO) treated by pelvic lymphadenectomy and the implantation of grains of I 125 in the prostatic tissue. Irradiation continued for six months, providing most dose of 100 Gy in the prostate. Interstitial irradiation caused not only the destruction of tumour cells but also "radiation prostate" lesions with vascular obliteration which itself caused sufficient impairment of the vitality of the prostatic tissue for any residual tumour to disappear with a frequency which increased with the time elapsing between the follow up prostatic biopsy and the implantation of radioactive iodine. Experience remains limited but the initial figures given here suggest the validity of continuing along these lines.
作者报告了一项对12例局限于前列腺的前列腺癌（T1、T2、T3、N0、M0）患者的初步研究，这些患者接受了盆腔淋巴结清扫术，并在前列腺组织中植入了碘125粒子。照射持续6个月，前列腺的最大剂量为100 Gy。间质照射不仅导致肿瘤细胞的破坏，还引发了伴有血管闭塞的“放射性前列腺”病变，这本身就足以损害前列腺组织的活力，使得任何残留肿瘤消失，其消失频率随着前列腺活检与放射性碘植入之间时间的推移而增加。经验仍然有限，但此处给出的初步数据表明沿这些方向继续研究的有效性。
