Elias M S, Evans P D
J Neurochem. 1983 Aug;41(2):562-8. doi: 10.1111/j.1471-4159.1983.tb04776.x.
The distribution of histamine in the nervous systems of the locust, the cockroach, and the sphinx moth was mapped and the capacity of locust nervous tissue to synthesise and metabolise histamine was assessed. In all three species the highest levels of histamine were present in the retina and in the lamina neuropil of the optic lobe. Lower levels of histamine were detectable throughout the nervous system. In the locust the retina was shown to synthesise considerable quantities of histamine. The optic lobe and metathoracic ganglion synthesised smaller, though significant, amounts of histamine. Metabolic inactivation of histamine in locust nervous tissue was shown to occur primarily via oxidation to imidazole-4-acetic acid and via N-acetylation to N-acetyl histamine. Whereas the retina and the optic lobe formed the two metabolic products in approximately equal proportions, the metathoracic ganglion produced almost three times as much N-acetyl histamine as imidazole-4-acetic acid.
绘制了组胺在蝗虫、蟑螂和天蛾神经系统中的分布图谱，并评估了蝗虫神经组织合成和代谢组胺的能力。在所有这三个物种中，组胺含量最高的部位是视网膜和视叶的板层神经毡。在整个神经系统中都可检测到较低水平的组胺。在蝗虫中，视网膜被证明能合成大量组胺。视叶和后胸神经节合成的组胺量较少，但也很显著。蝗虫神经组织中组胺的代谢失活主要通过氧化生成咪唑-4-乙酸和通过N-乙酰化生成N-乙酰组胺。视网膜和视叶生成这两种代谢产物的比例大致相等，而后胸神经节产生的N-乙酰组胺几乎是咪唑-4-乙酸的三倍。
