Baden-Kristensen K, Weiss T F
J Physiol. 1983 Feb;335:699-721. doi: 10.1113/jphysiol.1983.sp014559.
Receptor potentials of single hair cells in the free-standing region of the basilar papilla of the anaesthetized alligator lizard were measured intracellularly with micropipettes. Stimuli were primarily acoustic pulses (clicks) delivered to the tympanic membrane. The receptor potential was independent of click repetition rate for the range 10-150 clicks/s. This property is presumed to be the basis of the rate independence of the extracellular cochlear microphonic potential. The receptor potential wave-form consisted of a fast oscillatory component (or oscillation) superimposed on a usually positive (depolarizing) slow component. Reversal of the stimulus polarity resulted in a reversal of the polarity of the oscillations; the polarity of the slow component remained unchanged. The relative magnitudes of the two components depended on click level. At the higher click levels the magnitudes of the slow and oscillatory components were comparable. The relation of the receptor potential to the stimulus was non-linear; the peak-to-peak magnitude of the receptor potential increased less than proportionately with increasing sound-pressure level, and reversal of the stimulus polarity did not result in a reversal of the receptor potential. The receptor-potential magnitude for high-level clicks ranged from 1-13 mV peak-to-peak with an average value of 3.5 mV. At the lower click levels the magnitude of the slow component was much smaller than that of the oscillatory component. The relation of the receptor potential to the acoustic stimulus approached that of a linear system, the magnitude of the receptor potential became approximately proportional to the sound-pressure level, and reversal of the stimulus polarity resulted in approximate reversal of the receptor potential. For low-level stimuli the frequency of the oscillations of the receptor potential in response to clicks was approximately equal to the frequency of maximal a.c. response to tones. Apparently, both phenomena reflect the frequency selectivity of the processes generating the receptor potential. The frequency of oscillations in the click response varied from one cell to another (range of 1.0-2.2 kHz in this study). The results are qualitatively consistent with a model (Weiss, Mulroy & Altmann, 1974) that contains a linear, band-pass filter followed by a rectifier followed by a low-pass filter.
用微电极对麻醉的美洲蜥蜴基底乳头独立区域的单个毛细胞的感受器电位进行了细胞内测量。刺激主要是施加到鼓膜的声脉冲（滴答声）。在10 - 150次滴答声/秒的范围内，感受器电位与滴答声重复率无关。这一特性被认为是细胞外耳蜗微音器电位频率独立性的基础。感受器电位波形由叠加在通常为正（去极化）的慢成分上的快速振荡成分（或振荡）组成。刺激极性反转导致振荡极性反转；慢成分的极性保持不变。两个成分的相对大小取决于滴答声强度。在较高的滴答声强度下，慢成分和振荡成分的大小相当。感受器电位与刺激的关系是非线性的；感受器电位的峰峰值幅度随声压级增加的增加小于成比例增加，并且刺激极性反转不会导致感受器电位反转。高强度滴答声的感受器电位幅度在峰峰值1 - 13 mV范围内，平均值为3.5 mV。在较低的滴答声强度下，慢成分的幅度远小于振荡成分。感受器电位与声刺激的关系接近线性系统，感受器电位的幅度与声压级大致成比例，并且刺激极性反转导致感受器电位大致反转。对于低强度刺激，感受器电位对滴答声的振荡频率大约等于对纯音的最大交流反应频率。显然，这两种现象都反映了产生感受器电位过程的频率选择性。对滴答声反应的振荡频率在不同细胞之间有所不同（本研究中范围为1.0 - 2.2 kHz）。结果在定性上与一个模型（Weiss、Mulroy和Altmann，1974）一致，该模型包含一个线性带通滤波器，后面跟着一个整流器，再后面跟着一个低通滤波器。
